Background: Sedentary lifestyle and lack of exercise cause cardiovascular diseases and metabolic syndrome. Decreased movement in recent decades has caused cardiovascular diseases. Methods: In this research, 35 male Wistar rats weighing 220 ±,20 g were divided into 5 groups (seven rats in each group) by a simple randommethod. The first and second experimental groups were given 100 grams per liter of fructose with water for 6 weeks, and the third experimental group received this for 14 weeks. The training group performed the interval training protocol on the treadmill for eight weeks and 5 days a week. One-way analysis of variance (ANOVA) was used to compare the groups. Results: The use of the fructose diet for6weeksand14 weeks caused metabolicsyndromeinmaleWistar rats. Induction of metabolic syndrome increased the plasma levels of PTX3, VACM-1, and CRP at the end of 6 weeks (P = 0. 001, P = 0. 018, and P = 0. 004, respectively) and the fourteenth week (P = 0. 001, P = 0. 001, and P = 0. 001, respectively). Eight weeks of interval training significantly reduced PTX3, VACM-1, and CRP (P = 0. 034, P = 0. 027 and P = 0. 021, respectively). Conclusions: The fructose diet caused metabolic syndrome and a significant increase in inflammatory markers in rats, and high-intensity interval training significantly reduced inflammatory factors in them.